Familial adenomatous polyposis in two Black South African families.

@article{Grobbelaar2002FamilialAP,
  title={Familial adenomatous polyposis in two Black South African families.},
  author={Johanna J Grobbelaar and E Wilken and Thomy de Ravel and Daniel L. Nicholson and Maritha J. Kotze},
  journal={Clinical genetics},
  year={2002},
  volume={61 3},
  pages={214-7}
}
The apparent low incidence of colon cancer in the Black population of South Africa has been ascribed to a non-Western diet. The present authors report the identification of two common 5-bp deletions at codons 1309 and 1061 of the adenomatous polyposis coli (APC) gene in a Xhosa and Zulu patient, respectively. The in vitro transcription/translation test (PTT… CONTINUE READING