Familial Wilms' tumor with neural elements: characterization by histology, immunohistochemistry, and genetic analysis.

@article{Hussong2000FamilialWT,
  title={Familial Wilms' tumor with neural elements: characterization by histology, immunohistochemistry, and genetic analysis.},
  author={Jerry W. Hussong and Sherrie L. Perkins and Vicki Huff and J. Matthew McDonald and Theodore J. Pysher and J. Bruce Beckwith and Cheryl M. Coffin},
  journal={Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society},
  year={2000},
  volume={3 6},
  pages={561-7}
}
Wilms' tumor (WT) is the most common renal malignancy of children. While most occur sporadically, a small percentage are familial or occur as part of a developmental syndrome. Classic WTs exhibit a triphasic histologic pattern composed of blastema, epithelium, and stroma. Occasionally, heterologous elements may also be observed. In this study we investigated a series of four WTs that occurred within a single familial aggregate and contained focal areas of neural differentiation. The tumors were… CONTINUE READING