Familial Wiedemann-Beckwith syndrome and a second Wilms tumor locus both map to 11p15.5.

@article{Koufos1989FamilialWS,
  title={Familial Wiedemann-Beckwith syndrome and a second Wilms tumor locus both map to 11p15.5.},
  author={Alex Koufos and P. Grundy and Kenneth Morgan and Kyrieckos A. Aleck and T A Hadro and Beatrice C. Lampkin and A Kalbakji and Webster K Cavenee},
  journal={American journal of human genetics},
  year={1989},
  volume={44 5},
  pages={711-9}
}
Wilms tumor of the kidney occurs with increased frequency in association with two clinically and cytogenetically distinct congenital syndromes, the Wiedemann-Beckwith syndrome (WBS) and the triad of aniridia, genitourinary anomalies, and mental retardation (WAGR). Constitutional deletions in the latter situation and similar alterations in sporadic Wilms tumors have implicated the chromosomal 11p13 region in neoplastic development. In contrast, some sporadic cases of WBS have been reported to… CONTINUE READING