Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

  title={Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase},
  author={Hideki Shimura and Nobutaka Hattori and Shin-ichiro Kubo and Yoshikuni Mizuno and Shuichi Asakawa and Shinsei Minoshima and Nobuyoshi Shimizu and Kazuhiro Iwai and Tomoki Chiba and Keiji Tanaka and Toshiaki Suzuki},
  journal={Nature Genetics},
Autosomal recessive juvenile parkinsonism (AR–JP), one of the most common familial forms of Parkinson disease, is characterized by selective dopaminergic neural cell death and the absence of the Lewy body, a cytoplasmic inclusion body consisting of aggregates of abnormally accumulated proteins. We previously cloned PARK2, mutations of which cause AR–JP (ref. 2), but the function of the gene product, parkin, remains unknown. We report here that parkin is involved in protein degradation as a… CONTINUE READING
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