Familial Mediterranean fever: clinical and genetic characterization in a mixed pediatric population of Jewish and Arab patients.

@article{Brik1999FamilialMF,
  title={Familial Mediterranean fever: clinical and genetic characterization in a mixed pediatric population of Jewish and Arab patients.},
  author={Riva Brik and Marwan Shinawi and Ilana Kepten and Moshe Berant and Ruth Gershoni-baruch},
  journal={Pediatrics},
  year={1999},
  volume={103 5},
  pages={e70}
}
OBJECTIVE Familial Mediterranean fever (FMF) is an autosomal recessive hereditary disease which primarily affects non-Ashkenazi Jews, Armenians, Arabs, and Turks. The gene responsible for the disease (MEFV/FMF) has been recently identified. Four common mutations in exon 10 of the MEFV gene seem to account for 86% of the DNA variations identified in patients with FMF. We conducted a phenotype/genotype correlation study in a mixed population of Jewish and Arab children with FMF. STUDY DESIGN… CONTINUE READING
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