Familial Hypertrophic Cardiomyopathy Mice Display Gender Differences in Electrophysiological Abnormalities

@article{Berul1998FamilialHC,
  title={Familial Hypertrophic Cardiomyopathy Mice Display Gender Differences in Electrophysiological Abnormalities},
  author={Charles I. Berul and Michael E. Christe and Mark J. Aronovitz and Colin T. Maguire and Christine E Seidman and Jonathan G Seidman and Michael E. Mendelsohn},
  journal={Journal of Interventional Cardiac Electrophysiology},
  year={1998},
  volume={2},
  pages={7-14}
}
Genetically-manipulated mice harboring an α-myosin heavy chain Arg403Gln missense mutation (α-MHC 403/+ ) display a phenotype characteristic of familial hypertrophic cardiomyopathy (FHC). Male and female (30±8 week old) heterozygous α-MHC 403/+ mice and littermate controls were evaluated using a surface electrocardiogram (ECG) and an in vivo cardiac electrophysiology study (EPS). Wild type animals had normal intracardiac electrophysiology, with no significant differences between male and female… CONTINUE READING
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