Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

@article{Borchelt1996FamilialAD,
  title={Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo},
  author={D. Borchelt and G. Thinakaran and C. Eckman and M. K. Lee and F. Davenport and T. Ratovitsky and C. Prada and G. Kim and Sophia Seekins and D. Yager and H. Slunt and R. Wang and M. Seeger and A. Levey and S. Gandy and N. Copeland and N. Jenkins and D. Price and S. Younkin and S. Sisodia},
  journal={Neuron},
  year={1996},
  volume={17},
  pages={1005-1013}
}
Mutations in the presenilin 1 (PS1) and presenilin 2 genes cosegregate with the majority of early-onset familial Alzheimer's disease (FAD) pedigrees. We now document that the Abeta1-42(43)/Abeta1-40 ratio in the conditioned media of independent N2a cell lines expressing three FAD-linked PS1 variants is uniformly elevated relative to cells expressing similar levels of wild-type PS1. Similarly, the Abeta1-42(43)/Abeta1-40 ratio is elevated in the brains of young transgenic animals coexpressing a… Expand
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