Familial Aggregation of Irritable Bowel Syndrome: A Family Case–Control Study

@article{Saito2010FamilialAO,
  title={Familial Aggregation of Irritable Bowel Syndrome: A Family Case–Control Study},
  author={Yuri A Saito and Gloria M Petersen and Joseph J. Larson and Elizabeth J. Atkinson and Brooke L. Fridley and Mariza de Andrade and Giles Richard Locke and Janice Zimmerman and Ann E Almazar-Elder and Nicholas J Talley},
  journal={The American Journal of Gastroenterology},
  year={2010},
  volume={105},
  pages={833-841}
}
OBJECTIVES:Irritable bowel syndrome (IBS) clusters in families, but previous studies documented family history only from patients. We have shown that patient–relative agreement on IBS status is poor. Thus, we conducted a family case–control study with direct survey of symptoms from family members to better quantitate the aggregation of IBS in families. The aims of this study were to (i) compare the prevalence of IBS in case-relatives with control-relatives, and (ii) determine whether gender… CONTINUE READING

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