Familial Aggregation of Irritable Bowel Syndrome: A Family Case–Control Study

@article{Saito2010FamilialAO,
  title={Familial Aggregation of Irritable Bowel Syndrome: A Family Case–Control Study},
  author={Y. Saito and G. Petersen and J. Larson and E. Atkinson and B. Fridley and M. Andrade and G. Locke and J. Zimmerman and Ann E Almazar-Elder and N. Talley},
  journal={The American Journal of Gastroenterology},
  year={2010},
  volume={105},
  pages={833-841}
}
OBJECTIVES:Irritable bowel syndrome (IBS) clusters in families, but previous studies documented family history only from patients. We have shown that patient–relative agreement on IBS status is poor. Thus, we conducted a family case–control study with direct survey of symptoms from family members to better quantitate the aggregation of IBS in families. The aims of this study were to (i) compare the prevalence of IBS in case-relatives with control-relatives, and (ii) determine whether gender… Expand
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