False positive non‐synonymous polymorphisms of G‐protein coupled receptor genes

@article{Small2002FalsePN,
  title={False positive non‐synonymous polymorphisms of G‐protein coupled receptor genes},
  author={K. Small and Carrie A Seman and Alex Castator and K. Brown and S. Liggett},
  journal={FEBS Letters},
  year={2002},
  volume={516}
}
  • K. Small, Carrie A Seman, +2 authors S. Liggett
  • Published 2002
  • Biology, Medicine
  • FEBS Letters
  • Polymorphisms of G‐protein coupled receptor (GPCR) genes are associated with disease risk and modification, and the response to receptor‐directed therapy. Genomic sequencing (∼1700 automated runs) from as many as 120 chromosomes from 60 multiethnic individuals was performed to confirm non‐synonymous coding polymorphisms reported in the dbSNP database from 25 randomly selected GPCR genes. These polymorphisms were in regions of the receptors responsible for structural integrity, ligand binding, G… CONTINUE READING
    26 Citations

    Topics from this paper

    Gene and Protein Domain-Specific Patterns of Genetic Variability Within the G-Protein Coupled Receptor Superfamily
    • 27
    Comprehensive Analysis of Non-Synonymous Natural Variants of G Protein-Coupled Receptors
    • 5
    • PDF
    Sequence variation in G-protein-coupled receptors: analysis of single nucleotide polymorphisms
    • 40
    • PDF
    Spread and Disease Potential of Natural Variants in G Protein-Coupled Receptors
    • 2008
    Novel and nondetected human signaling protein polymorphisms.
    • 21
    • PDF
    Polymorphisms of adrenergic receptors: variations on a theme.
    • S. Liggett
    • Biology, Medicine
    • Assay and drug development technologies
    • 2003
    • 29
    Identification of functional SNPs in the 5-prime flanking sequences of human genes
    • 58
    • PDF

    References

    SHOWING 1-10 OF 23 REFERENCES
    Genetic variations and polymorphisms of G protein-coupled receptors: functional and therapeutic implications.
    • 98
    • PDF
    Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness.
    • 962
    • PDF
    A Gain-of-function Polymorphism in a G-protein Coupling Domain of the Human β1-Adrenergic Receptor*
    • 562
    • PDF
    Identification of adrenergic receptor polymorphisms.
    • 43
    Single-nucleotide polymorphisms in the public domain: how useful are they?
    • 167
    The Evolution of Drug Metabolism
    • 126
    • PDF