• DOI:10.1016/S0014-5793(02)02564-4
Corpus ID: 35944696

False positive non‐synonymous polymorphisms of G‐protein coupled receptor genes

@article{Small2002FalsePN,
  title={False positive non‐synonymous polymorphisms of G‐protein coupled receptor genes},
  author={K. Small and Carrie A Seman and Alex Castator and K. Brown and S. Liggett},
  journal={FEBS Letters},
  year={2002},
  volume={516}
}

K. Small, Carrie A Seman, +2 authors S. Liggett

Published 2002

Biology, Medicine

FEBS Letters

Polymorphisms of G‐protein coupled receptor (GPCR) genes are associated with disease risk and modification, and the response to receptor‐directed therapy. Genomic sequencing (∼1700 automated runs) from as many as 120 chromosomes from 60 multiethnic individuals was performed to confirm non‐synonymous coding polymorphisms reported in the dbSNP database from 25 randomly selected GPCR genes. These polymorphisms were in regions of the receptors responsible for structural integrity, ligand binding, G… CONTINUE READING

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