False-negative fine-needle aspiration cytology results delay treatment and adversely affect outcome in patients with thyroid carcinoma.

@article{Yeh2004FalsenegativeFA,
  title={False-negative fine-needle aspiration cytology results delay treatment and adversely affect outcome in patients with thyroid carcinoma.},
  author={Michael Yeh and Orhan Demircan and Philip H. G. Ituarte and Orlo Herrick Clark},
  journal={Thyroid : official journal of the American Thyroid Association},
  year={2004},
  volume={14 3},
  pages={207-15}
}
Clinicians have become reliant on fine-needle aspiration (FNA) cytology in the diagnosis of thyroid nodules. We encountered several patients who had thyroid cancer at operation despite having had FNAs that never showed malignant or suspicious cells. Hence, we retrospectively studied 100 consecutive patients with histologically proven thyroid cancer who had undergone preoperative FNA. Fourteen of these patients had cancers that were not detected by FNA, three of whom developed widespread disease… CONTINUE READING