False morel mushroom gyromitra esculenta toxin: N-methyl-N-formylhydrazine carcinogenesis in mice

@article{Tth2004FalseMM,
  title={False morel mushroom gyromitra esculenta toxin: N-methyl-N-formylhydrazine carcinogenesis in mice},
  author={B{\'e}la T{\'o}th and K D Patil and J. Erickson and Robert J. Kupper},
  journal={Mycopathologia},
  year={2004},
  volume={68},
  pages={121-128}
}
N-Methyl-N-formylhydrazine was administered in drinking water as a 0.0039% solution to randomly bred Swiss albino mice for life starting from 6 weeks of age. The compound induced tumors of lungs, livers, blood vessels, gall bladder and bile ducts. The tumor incidences in these five tissues were 77, 46, 21, 10 and 7%, while in the untreated controls they were 18, 1, 6, 0 and 0%, respectively. Histopathologically, the tumors were classified as adenomas and adenocarcinomas of lungs, benign… 
Tumorigenicity of minute dose levels of N-methyl-N-formylhydrazine of Gyromitra esculenta
TLDR
N-methyl-N-formylhydrazine is a stable constituent of the edible false morel mushroom Gyromitra esculenta and the environmental significance is discussed, in view of the carcinogenicity of minute doses of this chemical.
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  • Medicine
    Journal of Cancer Research and Clinical Oncology
  • 2004
TLDR
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TLDR
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The above results clearly indicate that high concentrations of inorganic phosphorous decrease the synthesis of tryptophan, ultimately inhibitingThe synthesis of alkaloids.
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