False discovery rate, sensitivity and sample size for microarray studies

@article{Pawitan2005FalseDR,
  title={False discovery rate, sensitivity and sample size for microarray studies},
  author={Yudi Pawitan and Stefan Michiels and Serge Koscielny and Arief Gusnanto and Alexander Ploner},
  journal={Bioinformatics},
  year={2005},
  volume={21 13},
  pages={
          3017-24
        }
}
MOTIVATION In microarray data studies most researchers are keenly aware of the potentially high rate of false positives and the need to control it. One key statistical shift is the move away from the well-known P-value to false discovery rate (FDR). Less discussion perhaps has been spent on the sensitivity or the associated false negative rate (FNR). The purpose of this paper is to explain in simple ways why the shift from P-value to FDR for statistical assessment of microarray data is… CONTINUE READING

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