False Negative Cytology in Large Thyroid Nodules

  title={False Negative Cytology in Large Thyroid Nodules},
  author={Wesley H. Giles and MMSc Reid A. Maclellan and MPH Atul A. Gawande and Daniel T. Ruan and Erik Karl Alexander and Francis D. Moore and Nancy L. Cho},
  journal={Annals of Surgical Oncology},
Controversy exists regarding the accuracy of fine-needle aspiration (FNA) in large thyroid nodules. Recent surgical series have documented false-negative rates ranging from 0.7 to 13 %. We examined the accuracy of benign FNA cytology in patients with thyroid nodules ≥3 cm who underwent surgical resection and identified features characteristic of false-negative results. We retrospectively studied all thyroidectomy specimens between January 2009 and October 2011 and identified nodules ≥3 cm with… CONTINUE READING


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