Faithful modeling of transient expression and its application to elucidating negative feedback regulation.

@article{Rubinstein2007FaithfulMO,
  title={Faithful modeling of transient expression and its application to elucidating negative feedback regulation.},
  author={Amir Rubinstein and Vyacheslav Gurevich and Zohar Kasulin-Boneh and Lilach Pnueli and Yona Kassir and Ron Y. Pinter},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 15},
  pages={6241-6}
}
Modeling and analysis of genetic regulatory networks is essential both for better understanding their dynamic behavior and for elucidating and refining open issues. We hereby present a discrete computational model that effectively describes the transient and sequential expression of a network of genes in a representative developmental pathway. Our model system is a transcriptional cascade that includes positive and negative feedback loops directing the initiation and progression through meiosis… CONTINUE READING
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