Failure to up-regulate VEGF165b in maternal plasma is a first trimester predictive marker for pre-eclampsia

@inproceedings{Bills2009FailureTU,
  title={Failure to up-regulate VEGF165b in maternal plasma is a
                    first trimester predictive marker for pre-eclampsia},
  author={Victoria L. Bills and Julia Varet and Ann B. Millar and Steve Harper and Peter W. Soothill and David W Bates},
  booktitle={Clinical science},
  year={2009}
}
Pre-eclampsia is a pregnancy-related condition characterized by hypertension, proteinuria and endothelial dysfunction. VEGF(165)b, formed by alternative splicing of VEGF (vascular endothelial growth factor) pre-mRNA, inhibits VEGF(165)-mediated vasodilation and angiogenesis, but has not been quantified in pregnancy. ELISAs were used to measure means+/-S.E.M. plasma VEGF(165)b, sEng (soluble endoglin) and sFlt-1 (soluble fms-like tyrosine kinase-1). At 12 weeks of gestation, the plasma VEGF(165… CONTINUE READING