Failure to respond autonomically to anticipated future outcomes following damage to prefrontal cortex.

  title={Failure to respond autonomically to anticipated future outcomes following damage to prefrontal cortex.},
  author={Antoine Bechara and Daniel Tranel and Hanna Damasio and Antonio R. Damasio},
  journal={Cerebral cortex},
  volume={6 2},
Following damage to specific sectors of the prefrontal cortex, humans develop a defect in real-life decision making, in spite of otherwise normal intellectual performance. The patients so affected may even realize the consequences of their actions but fail to act accordingly, thus appearing oblivious to the future. The neural basis of this defect has resisted explanation. Here we identify a physiological correlate for the defect and discuss its possible significance. We measured the skin… 

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