Failure to release iron from transferrin in a Chinese hamster ovary cell mutant pleiotropically defective in endocytosis

@article{Klausner1984FailureTR,
  title={Failure to release iron from transferrin in a Chinese hamster ovary cell mutant pleiotropically defective in endocytosis},
  author={R. Klausner and J. van Renswoude and C. Kempf and K. Rao and J. Bateman and A. Robbins},
  journal={The Journal of Cell Biology},
  year={1984},
  volume={98},
  pages={1098 - 1101}
}
  • R. Klausner, J. van Renswoude, +3 authors A. Robbins
  • Published 1984
  • Biology, Medicine
  • The Journal of Cell Biology
  • A Chinese hamster ovary cell mutant defective in the receptor-mediated endocytosis of several unrelated ligands (Robbins, A. R., S. S. Peng, and J. L. Marshall, 1983, J. Cell Biol., 96:1064-1071) failed to accumulate iron provided in the form of diferric transferrin. Analysis of the steps of the transferrin cycle indicated that binding and internalization of transferrin proceeded normally in mutant cells. However, the mutant appeared unable to dissociate iron from transferrin, as evidenced by… CONTINUE READING
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