Failure to relate the anti-tumour action of cyclophosphamide with the immunogenicity of two murine fibrosarcomas.


A single intraperitoneal injection of cyclophosphamide (CY) had a stronger anti-tumour effect upon two syngeneic mouse fibrosarcomas when given within a few days of tumour implantation than when given 7-20 days after. CY was more active against the fast-growing, relatively non-immunogenic CBA fibrosarcoma, FS13, inducing a higher proportion and permanent… (More)


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