Failure to improve the effect of thrombolysis by memantine in a rat embolic stroke model.

@article{Back2007FailureTI,
  title={Failure to improve the effect of thrombolysis by memantine in a rat embolic stroke model.},
  author={Tobias Back and D{\"o}rte Otto and Daniela Kittner and Olaf G. Sch{\"u}ler and Michael Hennerici and H. -D. Mennel},
  journal={Neurological research},
  year={2007},
  volume={29 3},
  pages={264-9}
}
OBJECTIVES Partial and delayed recanalization is a regular finding after thrombolysis in stroke patients who may benefit from additional therapy with neuroprotectants. To translate this scenario into an experiment, memantine was combined with thrombolysis in an embolic stroke model and tissue outcome was assessed in terms of complete and incomplete damage. METHODS Tissue plasminogen activator (tPA, 5 mg/kg, b.w.) was administered 1.5 or 3.5 hours after embolic middle cerebral artery (MCA… CONTINUE READING