Failure to discriminate initiation from promotion of liver tumors in a long-term study with the phenobarbital-type inducer alpha-hexachlorocyclohexane and the role of sustained stimulation of hepatic growth and monooxygenases.

@article{SchulteHermann1981FailureTD,
  title={Failure to discriminate initiation from promotion of liver tumors in a long-term study with the phenobarbital-type inducer alpha-hexachlorocyclohexane and the role of sustained stimulation of hepatic growth and monooxygenases.},
  author={Rolf Schulte-Hermann and Wolfram Parzefall},
  journal={Cancer research},
  year={1981},
  volume={41 10},
  pages={4140-6}
}
alpha-Hexachlorocyclohexane (alpha-HCH) was administered p.o. to female Wistar rats for periods of up to 33 months; doses were 20 mg/kg/day, 200 mg/kg every second week, or 420 mg/kg every third week. Increases of liver size, DNA, RNA, and protein (by 50 to 100%) and of drug-metabolizing enzyme activities (up to 300%) observed previously after single doses of alpha-HCH were found to persist after approximately one-third, 1, and 2 years of treatment. At 1 and 2 years, DNA synthesis was measured… CONTINUE READING

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The results show that determination of tumor numbers alone in a long - term animal experiment does not allow one to decide whether alpha - HCH ( and similar " xenobiotic inducers " ) is an initiating carcinogen or merely promotes tumorigenesis from " spontaneous " lesions .
The results show that determination of tumor numbers alone in a long - term animal experiment does not allow one to decide whether alpha - HCH ( and similar " xenobiotic inducers " ) is an initiating carcinogen or merely promotes tumorigenesis from " spontaneous " lesions .
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