Failure to confirm estrogenic activity for benzoic acid and clofibrate: implications for lists of endocrine-disrupting agents.

@article{Ashby1997FailureTC,
  title={Failure to confirm estrogenic activity for benzoic acid and clofibrate: implications for lists of endocrine-disrupting agents.},
  author={John Ashby and P. A. Lefevre and Jenny Odum and Helen Tinwell and S J Kennedy and N Beresford and John P. Sumpter},
  journal={Regulatory toxicology and pharmacology : RTP},
  year={1997},
  volume={26 1 Pt 1},
  pages={
          96-101
        }
}
Earlier reports that benzoic acid is uterotrophic to the rat and mouse and that clofibrate is uterotrophic to the rat have not been confirmed. The studies reported here involved the use of a range of test protocols and dose levels, including the protocols/dose levels used by the original investigators. In addition, both chemicals were inactive in a human estrogen receptor (hER alpha) yeast estrogenicity assay. It is concluded that benzoic acid and clofibrate are not estrogenic in the assays… CONTINUE READING

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