Failure to confirm association between PDCD1 polymorphisms and rheumatoid arthritis in a Japanese population

@article{Iwamoto2007FailureTC,
  title={Failure to confirm association between PDCD1 polymorphisms and rheumatoid arthritis in a Japanese population},
  author={Takuji Iwamoto and Katsunori Ikari and E. Tanaka To. Inoue and Yoshiaki Toyama and Masako Hara and Hisashi Yamanaka and Taisuke Tomatsu and Shigeki Momohara and Naoyuki Kamatani},
  journal={Journal of Human Genetics},
  year={2007},
  volume={52},
  pages={557-560}
}
AbstractProgrammed cell death 1 (PDCD1) is a necessary negative regulator to maintain peripheral tolerance and is a key molecule in the development of autoimmune diseases. Although PDCD1 gene polymorphisms and haplotypes were reported to be associated with rheumatoid arthritis (RA), replication studies later on showed conflicting results. Here, we analyzed the association of PDCD1 with RA using a large series of Japanese RA patients and population-based controls. DNA samples were obtained from… CONTINUE READING
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