Failure to activate the IFN-β promoter by a paramyxovirus lacking an interferon antagonist☆

@inproceedings{Killip2011FailureTA,
  title={Failure to activate the IFN-β promoter by a paramyxovirus lacking an interferon antagonist☆},
  author={M. J. Killip and D. F. Young and C S Ross and Shu Chen and Steve Goodbourn and R. E. Randall},
  booktitle={Virology},
  year={2011}
}
It is generally thought that pathogen-associated molecular patterns (PAMPs) responsible for triggering interferon (IFN) induction are produced during virus replication and, to limit the activation of the IFN response by these PAMPs, viruses encode antagonists of IFN induction. Here we have studied the induction of IFN by parainfluenza virus type 5 (PIV5) at the single-cell level, using a cell line expressing GFP under the control of the IFN-β promoter. We demonstrate that a recombinant PIV5… CONTINUE READING

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References

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Showing 1-10 of 45 references

Recognition of viruses by cytoplasmic sensors.

Current opinion in immunology • 2010
View 1 Excerpt

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