Failure to Censor Forbidden Clones of CD4 T Cells in Autoimmune Diabetes

@article{Lesage2002FailureTC,
  title={Failure to Censor Forbidden Clones of CD4 T Cells in Autoimmune Diabetes},
  author={Sylvie Lesage and Suzanne B. Hartley and Srinivas Akkaraju and Judith A. Wilson and Michelle J Townsend and Christopher C. Goodnow},
  journal={The Journal of Experimental Medicine},
  year={2002},
  volume={196},
  pages={1175 - 1188}
}
Type 1 diabetes and other organ-specific autoimmune diseases often cluster together in human families and in congenic strains of NOD (nonobese diabetic) mice, but the inherited immunoregulatory defects responsible for these diseases are unknown. Here we track the fate of high avidity CD4 T cells recognizing a self-antigen expressed in pancreatic islet beta cells using a transgenic mouse model. T cells of identical specificity, recognizing a dominant peptide from the same islet antigen and major… CONTINUE READING

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