Failure of thrombus to resolve in urokinase-type plasminogen activator gene-knockout mice: rescue by normal bone marrow-derived cells.

@article{Singh2003FailureOT,
  title={Failure of thrombus to resolve in urokinase-type plasminogen activator gene-knockout mice: rescue by normal bone marrow-derived cells.},
  author={Inder R Singh and Kevin Guiver Burnand and Mike Collins and Aernout Luttun and D{\'e}sir{\'e} Collen and B Boelhouwer and Alberto Smith},
  journal={Circulation},
  year={2003},
  volume={107 6},
  pages={869-75}
}
BACKGROUND Monocytes may have an important role in the resolution of venous thrombosis. Increased expression of tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) is associated with an ingress of monocytes into the thrombus. This study was designed to evaluate the importance of these activators in thrombus resolution. METHODS AND RESULTS Inferior caval vein thrombosis was induced in cohorts of adult wild-type, uPA gene-knockout (uPA-/-), and tPA gene… CONTINUE READING

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