Failure of the sulfhydryl donor N-acetylcysteine (NAC) to reverse nitrate tolerance in large epicardial arteries and the venous capacitance system of the dog.

Abstract

NAC has been thought to reverse nitrate tolerance by replenishing depleted intracellular sulfhydryl groups, however data on interactions between N-acetylcysteine and nitrates in patients with stable angina are controversial and disappointing. Therefore, we studied the effect of NAC on nitrate responsiveness of epicardial arteries and of the venous system… (More)

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@article{Muenzel1989FailureOT, title={Failure of the sulfhydryl donor N-acetylcysteine (NAC) to reverse nitrate tolerance in large epicardial arteries and the venous capacitance system of the dog.}, author={TM. Muenzel and Jane Bliss Holtz and Alexander Muelsch and D. J. Stewart and Eberhard Bassenge}, journal={Zeitschrift fur Kardiologie}, year={1989}, volume={78 Suppl 2}, pages={26-8; discussion 64-7} }