Failure of prophylactically administered phenytoin to prevent early posttraumatic seizures.

@article{Young1983FailureOP,
  title={Failure of prophylactically administered phenytoin to prevent early posttraumatic seizures.},
  author={Byron A Young and Robert P. Rapp and James A. Norton and Doris Haack and Phillip A. Tibbs and Jules Bean},
  journal={Journal of neurosurgery},
  year={1983},
  volume={58 2},
  pages={231-5}
}
A randomized double-blind placebo-controlled study was carried out to determine whether phenytoin administered soon after injury lessens the incidence of epilepsy in the 1st week after severe head trauma. In this study, 244 patients were randomized into either a phenytoin or placebo group. The patients in the phenytoin group were administered phenytoin intravenously or intramuscularly within 24 hours of hospital admission. Patients in the placebo group received intravenous or intramuscular… CONTINUE READING

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