Failure of prophylactic intravenous immunoglobulin to prevent sensitization to cryopreserved allograft tissue used in congenital cardiac surgery.

@article{Meyer2007FailureOP,
  title={Failure of prophylactic intravenous immunoglobulin to prevent sensitization to cryopreserved allograft tissue used in congenital cardiac surgery.},
  author={Steven R. Meyer and David B. Ross and Karen Forbes and Lois E Hawkins and Anne M Halpin and Susan Nahirniak and Jennifer M Rutledge and Ivan M. Rebeyka and Patricia M. Campbell},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={2007},
  volume={133 6},
  pages={
          1517-23
        }
}
OBJECTIVE Cryopreserved allograft tissue used in the Norwood procedure for infants with hypoplastic left heart syndrome causes profound immunologic sensitization, which may complicate future transplantation. Intravenous immunoglobulin has been shown to reduce sensitization after it has developed, allowing successful transplantation. The purpose of this pilot trial was to determine whether intravenous immunoglobulin given before and after the procedure could prevent sensitization to… CONTINUE READING