Failure of programmed cell death and differentiation as causes of tumors: some simple mathematical models.

@article{Tomlinson1995FailureOP,
  title={Failure of programmed cell death and differentiation as causes of tumors: some simple mathematical models.},
  author={Ian P. M. Tomlinson and Walter F. Bodmer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 24},
  pages={11130-4}
}
Most models of tumorigenesis assume that the tumor grows by increased cell division. In these models, it is generally supposed that daughter cells behave as do their parents, and cell numbers have clear potential for exponential growth. We have constructed simple mathematical models of tumorigenesis through failure of programmed cell death (PCD) or differentiation. These models do not assume that descendant cells behave as their parents do. The models predict that exponential growth in cell… CONTINUE READING

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