Failure of oral DHEA treatment to increase local salivary androgen outputs of female patients with Sjögren's syndrome.

Abstract

OBJECTIVES Sjögren's syndrome (SS) is a female-dominant autoimmune disease characterized by androgen depletion and defective dehydroepiandrosterone (DHEA) processing enzymatic machinery in the salivary glands. We hypothesized that, because of these local failures, DHEA replacement therapy would be unable to improve the local androgen deficiency in SS… (More)
DOI: 10.3109/03009742.2011.580000

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