Failure of neuronal maturation in Alzheimer disease dentate gyrus.

  title={Failure of neuronal maturation in Alzheimer disease dentate gyrus.},
  author={Bin Li and Hidenaga Yamamori and Yoshitaka Tatebayashi and Bridget Shafit-Zagardo and Hitoshi Tanimukai and She Chen and Khalid Iqbal and Inge Grundke-Iqbal},
  journal={Journal of neuropathology and experimental neurology},
  volume={67 1},
The dentate gyrus, an important anatomic structure of the hippocampal formation, is one of the major areas in which neurogenesis takes place in the adult mammalian brain. Neurogenesis in the dentate gyrus is thought to play an important role in hippocampus-dependent learning and memory. Neurogenesis has been reported to be increased in the dentate gyrus of patients with Alzheimer disease, but it is not known whether the newly generated neurons differentiate into mature neurons. In this study… CONTINUE READING


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