Failure of neostigmine to prevent tubocurarine neuromuscular block in the isolated arm.

Abstract

Neostigmine failed to modify the development of neuromuscular block in the presence of a high local concentration of tubocurarine. Only when the concentration of tubocurarine was reduced, and a suitable concentration gradient established between the receptor area and the plasma, did neostigmine increase the rate of recovery from the action of non-depolarizing neuromuscular blocking agents.

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Cite this paper

@article{Feldman1980FailureON, title={Failure of neostigmine to prevent tubocurarine neuromuscular block in the isolated arm.}, author={Sheldon A Feldman and S. Agoston}, journal={British journal of anaesthesia}, year={1980}, volume={52 12}, pages={1199-1203} }