Failure of montelukast to reduce sputum eosinophilia in high-dose corticosteroid-dependent asthma.

  title={Failure of montelukast to reduce sputum eosinophilia in high-dose corticosteroid-dependent asthma.},
  author={Lata Jayaram and Mylinh T Duong and Marcia Margaret Menezes Pizzichini and Emilio Pizzichini and Dennis Kamada and Ann E Efthimiadis and Frederick E. Hargreave},
  journal={The European respiratory journal},
  volume={25 1},
Sputum eosinophilia is a sensitive predictor of benefit from corticosteroid treatment. Montelukast is a cysteinyl leukotriene antagonist, which also reduces sputum and blood eosinophils. The present study examined the possibility that montelukast has an added eosinophil-lowering effect in subjects with asthma who are corticosteroid responsive but relatively corticosteroid resistant. A total of 14 clinically stable adults with asthma requiring minimum treatment with a high-dose inhaled steroid… CONTINUE READING


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