Failure of microtubule-mediated peroxisome division and trafficking in disorders with reduced peroxisome abundance.

@article{Nguyen2006FailureOM,
  title={Failure of microtubule-mediated peroxisome division and trafficking in disorders with reduced peroxisome abundance.},
  author={Tam H. Nguyen and Jonas Bjorkman and Barbara C. Paton and Denis I. Crane},
  journal={Journal of cell science},
  year={2006},
  volume={119 Pt 4},
  pages={636-45}
}
In contrast to peroxisomes in normal cells, remnant peroxisomes in cultured skin fibroblasts from a subset of the clinically severe peroxisomal disorders that includes the biogenesis disorder Zellweger syndrome and the single-enzyme defect D-bifunctional protein (D-BP) deficiency, are enlarged and significantly less abundant. We tested whether these features could be related to the known role of microtubules in peroxisome trafficking in mammalian cells. We found that remnant peroxisomes in… CONTINUE READING
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