Failure of methylprednisolone acetate to prolong the antinauseant effect of intravenous methylprednisolone sodium succinate in patients receiving chemotherapy.

@article{Osoba1988FailureOM,
  title={Failure of methylprednisolone acetate to prolong the antinauseant effect of intravenous methylprednisolone sodium succinate in patients receiving chemotherapy.},
  author={David Osoba and Charles E Erlichman and Andrew R. Willan and Malcolm L Brigden and P H Geggie and Joseph L. Pater and James J. Rusthoven and Kenneth S Wilson},
  journal={Clinical and investigative medicine. Medecine clinique et experimentale},
  year={1988},
  volume={11 5},
  pages={377-9}
}
The efficacy of intramuscular methylprednisolone acetate in maintaining the antinauseant effect of intravenous methylprednisolone sodium succinate was assessed in a prospectively-randomized, double-blind, crossover-design trial. Of 150 patients entered, 127 were evaluable. There was no statistically significant difference between methylprednisolone acetate and saline placebo, although patient preferences slightly favoured the methylprednisolone acetate for nausea, vomiting, and overall… CONTINUE READING