Failure of insulin-like growth factor-I (IGF-I) infusion to promote growth in protein-restricted rats despite normalization of serum IGF-I concentrations.

@article{Thissen1991FailureOI,
  title={Failure of insulin-like growth factor-I (IGF-I) infusion to promote growth in protein-restricted rats despite normalization of serum IGF-I concentrations.},
  author={J. P. Thissen and Louis E. Underwood and Dominique Maiter and Marc Maes and David Robert Clemmons and Jean Marie Ketelslegers},
  journal={Endocrinology},
  year={1991},
  volume={128 2},
  pages={885-90}
}
Dietary protein restriction in young rats induces GH resistance characterized by growth arrest and low serum insulin-like growth factor-I (IGF-I) concentrations. To determine whether the low serum IGF-I concentrations are responsible for the stunted growth, we infused 4-week-old protein-restricted rats with recombinant human IGF-I (300 micrograms/day) or rat GH (200 micrograms/100 g body wt/day) by osmotic minipump for 1 week. Despite the normalization of serum IGF-I concentrations by IGF-I… CONTINUE READING

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