Failure of ibogaine to produce phencyclidine-like discriminative stimulus effects in rats and monkeys.

@article{Jones1998FailureOI,
  title={Failure of ibogaine to produce phencyclidine-like discriminative stimulus effects in rats and monkeys.},
  author={Hendr{\'e}e E Jones and He Li and Robert L. Balster},
  journal={Pharmacology, biochemistry, and behavior},
  year={1998},
  volume={59 2},
  pages={413-8}
}
The discriminative stimulus properties of ibogaine were investigated in rats trained to discriminate phencyclidine (PCP; 2.0 mg/kg, I.P.) from saline under a two-lever fixed-ratio (FR) 32 schedule of food reinforcement. Ibogaine (5.6-17.6 mg/kg, I.P.) showed a complete lack of substitution. Ibogaine (0.5-4.0 mg/kg, I.M.) also failed to generalize in rhesus monkeys trained to discriminate PCP (0.1 mg/kg, I.M.) from sham injection. Lysergic acid diethylamide (LSD), tested as a reference compound… CONTINUE READING