Failure of human immunodeficiency virus entry and infection in CD4-positive human brain and skin cells.

@article{Chesebro1990FailureOH,
  title={Failure of human immunodeficiency virus entry and infection in CD4-positive human brain and skin cells.},
  author={Bruce Chesebro and R S Buller and John L. Portis and Kathy Wehrly},
  journal={Journal of virology},
  year={1990},
  volume={64 1},
  pages={215-21}
}
CD4 molecules on human cells function as a major receptor for human immunodeficiency virus (HIV); however, certain CD4-negative cell types may also be susceptible to infection. Therefore, we attempted to quantitate the relationship between HIV infection and CD4 expression on human cell lines before and after introduction of the CD4 gene by using a retrovirus vector. Prior to introduction of the CD4 expression vector, low levels of HIV infection were detected by a sensitive focal immunoassay on… CONTINUE READING