Failure of host defenses in human immunodeficiency virus.

  title={Failure of host defenses in human immunodeficiency virus.},
  author={Judd E Shellito},
  journal={Seminars in respiratory and critical care medicine},
  volume={25 1},
  • Judd E Shellito
  • Published 2004 in
    Seminars in respiratory and critical care…
Infection with human immunodeficiency virus (HIV) creates systemic immunosuppression but induces unique alteration of immune functions within lung tissue as well. Cells within the lung, particularly the alveolar macrophage, are important reservoirs of HIV infection. The body's immune response to HIV-infected lung cells creates a persistent inflammatory environment within the alveolar space, which compromises host responses to infectious pathogens. HIV infection alters mucociliary function as… CONTINUE READING