Failure of hormone therapy in prostate cancer involves systematic restoration of androgen responsive genes and activation of rapamycin sensitive signaling

@article{Mousses2001FailureOH,
  title={Failure of hormone therapy in prostate cancer involves systematic restoration of androgen responsive genes and activation of rapamycin sensitive signaling},
  author={Spyro Mousses and Urs Wagner and Yidong Chen and Jung Woo Kim and Lukas Bubendorf and Michael Bittner and Thomas G. Pretlow and Abdel G. Elkahloun and Jane B. Trepel and O. -P. Kallioniemi},
  journal={Oncogene},
  year={2001},
  volume={20},
  pages={6718-6723}
}
Androgen deprivation therapy for advanced prostate cancer is often effective, but not curative. Molecular pathways mediating the therapeutic response and those contributing to the subsequent hormone-refractory cell growth remain poorly understood. Here, cDNA microarray analysis of human CWR22 prostate cancer xenografts during the course of androgen deprivation therapy revealed distinct global gene expression profiles in primary, regressing and recurrent tumors. Elucidation of the genes involved… CONTINUE READING

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