Failure of high doses of propranolol to reduce experimental myocardial ischemic damage.

@article{Peter1978FailureOH,
  title={Failure of high doses of propranolol to reduce experimental myocardial ischemic damage.},
  author={Thomas C. Peter and Ming K. Heng and Bramah N. Singh and P K Ambler and H I Nisbet and R. Stephen Elliot and Robin M Norris},
  journal={Circulation},
  year={1978},
  volume={57 3},
  pages={534-40}
}
Myocardial creatine phosphokinase (CPK) activity and myocardial blood flow (MFB, 15 +/- mu microspheres) were measured at 24 hours after ligation of the left anterior descending coronary artery in nine untreated anesthetized dogs, in eight dogs pretreated with intravenous propranolol 5 mg/kg and in eight which had both pretreatment as well as infusion of propranolol (1.25 mg/kg/hour) after occlusion. Loss of CPK activity from the border and center zones of the myocardial infarct was similar in… CONTINUE READING
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