Failure of high doses of propranolol to reduce experimental myocardial ischemic damage.

  title={Failure of high doses of propranolol to reduce experimental myocardial ischemic damage.},
  author={Thomas C. Peter and Ming K. Heng and Bramah N. Singh and P K Ambler and H I Nisbet and R. Stephen Elliot and Robin M Norris},
  volume={57 3},
Myocardial creatine phosphokinase (CPK) activity and myocardial blood flow (MFB, 15 +/- mu microspheres) were measured at 24 hours after ligation of the left anterior descending coronary artery in nine untreated anesthetized dogs, in eight dogs pretreated with intravenous propranolol 5 mg/kg and in eight which had both pretreatment as well as infusion of propranolol (1.25 mg/kg/hour) after occlusion. Loss of CPK activity from the border and center zones of the myocardial infarct was similar in… CONTINUE READING
7 Citations
35 References
Similar Papers


Publications referenced by this paper.
Showing 1-10 of 35 references

Propranolol - mediated increase in collateral flow during acute myocardial infarction

  • F Barcia, JS Borer, N Capuno, KM Kent
  • Circulation
  • 1976

Reduc - tion of infarct size by propranolol in closed - chest anesthetized dogs

  • M Miura, Ganz Wv, R Thomas, BN Singh, T Sokol, WE Shell
  • 1976

The effects of propranolol on myocardial energy stores during myocardial ischemia in dogs

  • A Obeid, R Spear, S Mookherjee, R Warner, R Eich
  • Circulation
  • 1976

Similar Papers

Loading similar papers…