Failure of high doses of alpha interferon to affect the growth of human carcinoma, melanoma, and myeloid leukaemia xenografts.

Abstract

Balkwill et al. (1980) observed that human leukocyte interferon (IFN) from lymphoblastoid cells prevented 2/3 human mammary carcinomas from growing as xenografts in genetically athymic nu/nu mice, but failed to slow the growth once the tumours had been established. Subsequently, Balkwill et al. (1982) found a mammary tumour, the growth of which as a xenograft was stopped by IFN-a when given 2 or 3 weeks after implantation. We failed to observe any effect of a highly purified human IFN-cx on a human malignant melanoma xenograft (HX34; Selby et al., 1980), a human lung adenocarcinoma xenograft (HX70; Shorthouse et al., 1980) and a xenograft of acute myeloid leukaemia (AML) cells in immunodeprived mice (Table I). The present experiments differed from those carried out by Balkwill et al. (1980) not only in the type of tumour employed, but also in the source of IFN-a and the nature of the murine host. We used IFN-a2 produced in E. coli by direct

DOI: 10.1038/bjc.1983.212

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@article{Clutterbuck1983FailureOH, title={Failure of high doses of alpha interferon to affect the growth of human carcinoma, melanoma, and myeloid leukaemia xenografts.}, author={R. D. Clutterbuck and John L. Millar and Peter G. Alexander}, journal={British Journal of Cancer}, year={1983}, volume={48}, pages={445 - 447} }