Failure of ergotamine to act as an amplifier of sulfonylurea-stimulated insulin secretion

Abstract

Normal dogs were injected i.v. with 0.25 mg/kg sodium salt of HB 419 (gliben-clamide) and plasma insulin concentrations were measured over a period of 2 hrs. When the animals were given a single i.v. injection of 0.2 mg/kg dihydroergotamine tartrate (DHE) 30 min prior to the administration of HB 419, the insulinogenic effect of the sulfonylurea was… (More)
DOI: 10.1007/BF02581300

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