Failure of elastic fiber homeostasis leads to pelvic floor disorders.

  title={Failure of elastic fiber homeostasis leads to pelvic floor disorders.},
  author={Xiaoqing Liu and Yun M. Zhao and Basil S. Pawlyk and Margot S. Damaser and Tiansen Li},
  journal={The American journal of pathology},
  volume={168 2},
Pelvic floor disorders, a group of conditions affecting adult women, include pelvic organ prolapse and urinary incontinence. Vaginal childbirth and aging are risk factors, and weakening of the pelvic support structures is a major aspect of the pathology. However, the underlying molecular mechanism remains unknown. Female reproductive organs are rich in elastic fibers that turn over slowly in most adult tissues but undergo massive remodeling in the reproductive organs through pregnancy and birth… CONTINUE READING