Failure of cytotoxic drugs to suppress immune responses of patients with rheumatoid arthritis.

@article{Denman1970FailureOC,
  title={Failure of cytotoxic drugs to suppress immune responses of patients with rheumatoid arthritis.},
  author={E J Denman and A Michael Denman and Brian Greenwood and Daniel Gall and R. B. Heath},
  journal={Annals of the rheumatic diseases},
  year={1970},
  volume={29 3},
  pages={220-31}
}
Cytotoxic drugs suppress many forms of immune and inflammatory response in animals (Gabrielsen and Good, 1967). It has been argued that their immunosuppressive properties justify the use of these drugs in the treatment of putative autoimmune diseases in man. As a result they have been used to treat chronic inflammatory diseases including rheumatoid arthritis (Mason, Currey, Barnes, Dunne, Hazleman, and Strickland, 1969). It is pertinent to ask, however, whether cytotoxic drugs do indeed… CONTINUE READING

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