Failure of cannabinoid compounds to stimulate estrogen receptors.

  title={Failure of cannabinoid compounds to stimulate estrogen receptors.},
  author={Mary F. Ruh and J. Andrew Taylor and Allyn C. Howlett and Wade V. Welshons},
  journal={Biochemical pharmacology},
  volume={53 1},
delta 9-Tetrahydrocannabinol (THC), the primary active compound in Cannabis sativa (marihuana), and other cannabinoid receptor agonists exert potent effects on luteinizing hormone and prolactin release in animal models and humans. Compounds possessing the tricyclic cannabinoid structure, including delta 9-THC and cannabidiol, have been reported to interact with rodent uterine estrogen receptors in ligand binding assays. The present study tested the hypothesis that cannabinoid compounds produce… CONTINUE READING