Failure of behavioral dependence induction and oral nicotine bioavailability in rats.

@article{Houezec1989FailureOB,
  title={Failure of behavioral dependence induction and oral nicotine bioavailability in rats.},
  author={J Le Houezec and Chantal Delon Martin and C Cohen and Robert Molimard},
  journal={Physiology & behavior},
  year={1989},
  volume={45 1},
  pages={103-8}
}
As failure to induce behavioral dependence to oral nicotine (0.31 mM) might be caused by taste aversion. Sixteen rats were presented nicotine around the taste aversion threshold (0.025 mM then 0.05 mM) as only source of fluid for 10 weeks. Eight of them had undergone portacaval anastomosis (PCA) to increase bioavailability of nicotine by preventing liver first-pass. Weekly choice sessions between nicotine and water demonstrated neither aversion nor preference for nicotine. In 10 control and 11… CONTINUE READING

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