Failure of Trimethoprim/Sulfamethoxazole Prophylaxis for Pneumocystis carinii Pneumonia with Concurrent Leucovorin Use

@article{Razavi2002FailureOT,
  title={Failure of Trimethoprim/Sulfamethoxazole Prophylaxis for Pneumocystis carinii Pneumonia with Concurrent Leucovorin Use},
  author={By Razavi and Benedicte Lund and Bradley L. Allen and Larry S. Schlesinger},
  journal={Infection},
  year={2002},
  volume={30},
  pages={41-42}
}
Pneumocystis carinii is a common cause of pneumonia in patients with AIDS, however, the incidence has dropped with the availability of effective prophylactic regimens. First-line treatment for both acute Pneumocystis pneumonia and chronic prophylaxis is trimethoprim/sulfamethoxazole (TMP/SMX). This combination can cause hypersensitivity reactions as well as myelosuppression. The simultaneous administration of leucovorin during acute treatment has bee shown to reduce the incidence of neutropenia… 
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