Failure of Ro 15-4513 to antagonize ethanol in rat lines selected for differential sensitivity to ethanol and in Wistar rats.


An imidazobenzodiazepine, Ro 15-4513, acting as a partial inverse agonist at the central benzodiazepine receptors has been recently reported to reverse efficiently the intoxicating effects of ethanol. In studies designed to delineate the role of benzodiazepine receptors in the ethanol-induced motor impairment difference between two rat lines selectively… (More)


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