Failure of HY-specific thymocytes to escape negative selection by receptor editing.

@article{Buch2002FailureOH,
  title={Failure of HY-specific thymocytes to escape negative selection by receptor editing.},
  author={Thorsten Buch and Fr{\'e}d{\'e}ric Rieux-Laucat and Irmgard Foerster and Klaus Rajewsky},
  journal={Immunity},
  year={2002},
  volume={16 5},
  pages={
          707-18
        }
}
Editing of autoreactive antigen receptors by secondary V(D)J recombination efficiently rescues B lymphocyte precursors from apoptosis induced by negative selection, but its role has not been rigorously assessed in T cell development. We therefore generated a transgenic mouse model in which self-reactive thymocytes could edit their TCR by secondary recombination at the TCR alpha locus. For this purpose, the V alpha J alpha exon of a male-specific TCR was inserted into the TCR alpha locus… CONTINUE READING

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